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AICAR, which has the scientific name 5-aminoimidazole-4-carboxamide-1-β-D-ribofuranoside, is an analog of adenosine monophosphate (AMP). By enhancing AMP-activated protein kinase (AMPK) activity in the body, it boosts cellular energy, improves the uptake of glucose and fatty acids in cells. In medical settings, it’s sometimes used for patients with cardiac ischemic injury. AICAR was originally created in the 1980s for maintaining blood flow to the heart during surgery. Research suggests it could help treat diabetes through its effects on cellular metabolic activity, whereby it improves glucose absorption and promotes the growth of lean muscle tissue .
According to a report published in “Drug Testing and Analysis,” AICAR is banned by the World Anti-Doping Agency (WADA) because of its performance-enhancing abilities. Urine needs to be tested within just 4 and a half hours after the drug has been taken, because it has a short lifespan in the system .
In a 2016 study published in “PLoS One,” researchers found that AICAR helps boost the metabolism of brown fat cells, suggesting its potential roll in body recomposition .
|IUPAC Name||5-Aminoimidazole-4-carboxamide ribonucleotide|