5F-MDMB-2201

Description

Pharmacokinetics:

Also known as 5F-MDMB-PICA, 5F-MDMB-2201 is one of the more common synthetic cannabinoids [1, 2]. It’s based on an indole core structure, in which the 1- and 3-positions of the indole ring system are replaced. The 1-position of 5F-MDMB-2201 is substituted with a linear 5-carbon chain terminated with a fluorine atom. Its 3-position is substituted with an amide linker, which has a nitrogen atom likewise substituted with a 1-methoxy-3,3-dimethyl-1-oxobutan-2-yl group [3]. In scientific nomenclature, the substance is written as Methyl (2S)-2-{[1-(5-fluoropentyl)-1H-indole-3-carbonyl]amino}-3,3-dimethylbutanoate (C₂₁H₂₉FN₂O₃) [1].

Scientific Studies:

According to a medical report published in “ACS Chemical Neuroscience” in 2016, 5F-MDMB-2201 binds tightly to the CB1 cannabinoid receptor. It acts as a potent agonist at the CB1 receptor, demonstrating even greater potency than THC in both in vitro and in vivo studies [4].

A later study, published in “Drug Testing and Analysis” in 2019, found that 5F-MDMB-2201 has a greater affinity for the CB1 receptor than JWH-018, making its effects comparatively more acute [5].

Sources:

1. https://isomerdesign.com/PiHKAL/explore.php?domain=tk&id=4493

2. https://ndews.umd.edu/sites/ndews.umd.edu/files/Emerging-Threat-Report-2018-Annual.pdf

3. https://www.deadiversion.usdoj.gov/drug_chem_info/5F-MDMB-PICA.pdf

4. https://www.ncbi.nlm.nih.gov/pubmed/27421060

5. https://www.ncbi.nlm.nih.gov/pubmed/31461219

IUPAC Name
CAS Number
Formula
Molar Mass