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N-Ethylhexedrone is a synthetic cathinone also known as NEH and hexen or hex-en. It was first developed and patented in the 1960s, and led to the development of methylenedioxypyrovalerone (MDPV), which is a better-known synthetic cathinone. N-Ethylhexedrone is a derivative of hexedrone and produces a psychostimulant effect by increasing levels of the neurotransmitters norepinephrine and dopamine in the brain. According to research, N-Ethylhexedrone is known to cause elevated heart rate and blood pressure, sweating, reduced appetite, tingling and increased stamina. Psychological effects have been shown to include thought acceleration, disinhibition, increased focus and motivation, ego inflation and euphoria. Adverse effects have included dehydration, dry mouth, teeth grinding and erectile dysfunction .
In a 2019 study published in Psychopharmacology that compared different synthetic cathinones, researchers determined that N-Ethylhexedrone and N-ethyl-pentylone had the highest affinities for dopamine transporters. This could imply that it has a higher potential for abuse compared to other synthetic cathinones, because of its high dopamine transporter selectivity .