S4 (Andarine)

S4 (Andarine)

S4 (Andarine)


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S4, also called Andarine, is a selective androgen receptor modulator (SARM) that was created to treat patients with osteoporosis and muscle wasting. It offers a high oral bioavailability, and its ability to increase muscle growth and bone density has been documented in animal studies [1]. As an androgen receptor agonist, S4 produces a testosterone-like effect, which is why S4 and other SARMs are used in the fitness community to help with building muscle. It’s also been tested by the medical community for its potential role in treating muscle wasting and osteoporosis [2]. Unlike steroids, S4 does not seem to affect sex hormone levels or produce any effects on sexual organs [3].

Because S4 is so effective in improving athletic performance while causing little to no side effects, it’s considered a doping agent and labs are able to screen for the metabolites that identify S4 with a simple urine test [4].

Scientific Studies:

According to an article published in the “Journal of Pharmacological & Experimental Theory,” both test tube and animal studies have demonstrated the clear effects of S4. It has a testosterone-like effect by increasing the anabolic activity selectively in just muscle and bone tissue. This speeds up the natural processes that take place in these tissues, such as muscle growth and bone-building [2].


1. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2072877/

2. https://www.ncbi.nlm.nih.gov/pubmed/12604714/

3. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4083371/

4. https://www.ncbi.nlm.nih.gov/pubmed/1316765

IUPAC Name S4 (Andarine)
CAS Number 401900-40-1


Molar Mass

441.357 g/mol


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