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SGT-25, also called 5F-CUMYL-PINACA, is an indazole-3-carboxamide-based synthetic cannabinoid. It’s an analogue of 5F-AB-PINACA, whereby the 1-amino-3-methyl-1-oxobutanyl group has been replaced with a cumyl group . SGT-25’s formal name is 1-(5-fluoropentyl)-N-(1-methyl-1-phenylethyl)-1H-indazole-3-carboxamide (C22H26FN3O) . Researchers have found that the cumyl moiety is what increases the potency significantly .
In lab studies, it’s been shown to have full agonistic affinity at the CB1 cannabinoid receptor. According to its original patent, the substance has about 4X selectivity for the CB1 receptor over the CB2 receptor . The chemical has been popularly manufactured as “C-liquid” used in electronic cigarettes .
In a 2019 German experiment published in “Forensic Toxicology,” one of the study’s authors performed a controlled self-experiment by ingesting 0.6 mg of SGT-25. An analysis of serum samples taken after ingestion showed that serum concentrations of SGT-25 increased within the first 7 hours after ingestion. Once peaking at about 7 hours, concentrations steadily declined for the next 10 to 12 hours .
Interestingly, the same study found that 5F-CUMYL-PINACA had less potency than its non-fluorinated analogue CUMYL-PINACA .