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Tianeptine is a type of antidepressant drug used as a nootropic to elevate mood. It’s an agonist of a type of opioid receptor, which is how it induces mild euphoria at higher doses. However, these doses could lead to potential health problems, particularly concerning your kidneys, heart and brain .
Tianeptine is 99 percent bioavailable, and it quickly metabolizes in your liver. With a half-life of 2 and a half to 3 hours, it’s out of the system within 6 hours .
In a 2014 study published in “Psychiatry Research,” tianeptine improved cognitive ability in patients with depression. Participants showed improvements in markers including memory, attention span, processing speed, executive function, learning function and more .
In a study published in “Neuroscience and Behavioral Physiology,” researchers looked at the effects of tianeptine on patients with Parkinson’s Disease who were also diagnosed with depression. After 3 months of supplementing with tianeptine, the average patient scores for depression improved by 34 percent, suggesting it has effective anti-depressant effects in cases of Parkinson’s Disease .